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This abnormal response leads to the production of high levels of cytokines, chemokines, growth factors, proteases and ROS, which exacerbate tissue injury and inflammation, and drive abnormal repair and airway remodelling ( 4.1 Epithelium-immune cell crosstalk The interaction of immune and epithelial cells is necessary to maintain tissue homeostasis ( 5 Airway epithelial dysfunction in asthma Asthma is a chronic inflammatory disease, characterized by a heightened, continued, and chronic immune response

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These substances can affect the central nervous system (CNS) in different ways

Sources and further reading: Wikipedia Gauloises, Wikipedia Smoking in France The Guardian.